The NEBNext UltraShear FFPE DNA Library Prep Kit includes NEBNext UltraShear, a new solution designed for enzymatic fragmentation of challenging samples; the NEBNext FFPE DNA Repair v2 Mix, an optimized cocktail of enzymes designed to repair FFPE DNA; library prep reagents featuring a new polymerase master mix, and a protocol optimized for FFPE DNA. NEBNext UltraShear further increases library yields and quality, while improving scalability and ease of use.